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At least eight different inherited disorders of cholesterol biosynthesis are recognized in humans that lead to congenital abnormalities in those afflicted, including developmental malformation and neurologic defects, while deficiencies in the enzymes responsible for the hydrolysis of cholesterol esters, such as the lysosomal acid lipase, occur in Wolman disease and cholesterol ester storage disease

Chirality 24 , 691698 (2012)

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also called LAP* and LAP) originate through regular translation initiation, and they are transcriptional activators

-KG can directly enter the TCA cycle, where it can be metabolized through oxidation and reduction

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