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A more detailed understanding of how mitophagy regulates mitochondrial ROS and ferroptosis in different contexts is needed

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12 , 24 In senescence, some of these processes become chronically dysregulated

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J Physiol (2016) 594(1):13547

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Is IV Vitamin Therapy Right for You

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Regulating TAM iron metabolism within the TIME, specifically by promoting iron uptake and storage in M2-type macrophages while inhibiting iron release, allows iron accumulation in TAMs to enhance ROS production, increase p300/CBP acetyltransferase activity, and promote p53 acetylation

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On this ground the WHO updated its DR-TB treatment guidelines in 2022 (WHO Consolidated Guidelines on Tuberculosis, 2024), recommending the 6-month BPaL-M regimen for MDR/Rifampicin-Resistant (RR)-TB in patients unexposed to bedaquiline, pretomanid, or linezolid (Johnson et al., 2024)

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