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Monoamine neurotransmitter disorders-clinical advances and future perspectives

Ascorbic acid-induced progression of quiescent centre cells from G1 to S phase

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This suggests that contacts outside of the ligand-binding site contribute to its improved affinity in the presence of ENL and, indeed, our model revealed an extensive interfacial interaction between CRBN and ENL YEATS, with a buried solvent-accessible surface area of ~2,258 2 and a high degree of shape complementarity (0.64 out of 1) 52

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Outside of genetic causes, copper has been found to be decreased in the Parkinsons disease brain corresponding to diminished cuproenzyme metallation and function linked to pathology 50,51,52,53,54