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Spink DC, Johnson JA, Connor SP, Aldous KM, Gierthy JF

& Hutter-Paier, B

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In addition, the activation of pancreatic stellate cells (PSCs) is a key mechanism for pancreatic islet fibrosis

Its long-term persistence can lead to liver fibrosis, cholangitis, and even progression to cirrhosis ( The role of the AhR in the cholestatic process exhibits significant complexity and duality, with its functional output highly dependent on ligand properties, disease stage, and cellular context