The accumulating body of evidence suggests that the liver toxicity of AFs is mainly associated with oxidative/nitrosative stress, cellular apoptosis, mitochondrial dysfunction, lipid/protein peroxidation, construction of AFs-DNA adducts, DNA damage, induction of genomic mutation, inhibition of tumor suppressor proteins, up-regulation of gene expression, induction of inflammatory signaling pathways (440)
Nonetheless, owing to the risks of drug resistance and potential gastrointestinal, cardiac, and auditory side effects, macrolides should be administered with caution, particularly in patients with nontuberculous mycobacterial infections or when such infections have not been conclusively ruled out
coli , and Turicibacter , leading to a reduction of the inflammation levels caused by dextran sodium sulfate (DSS) in mice
Minami, J
Generally, patients remain on the medication for a minimum of 3-4 months, allowing for significant weight loss and the development of healthy lifestyle habits
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