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Current and future immunotherapy approaches in ovarian cancer

doi: 10.1007/s00259-021-05294-3 108

PARs mediate tissue factor TF, which then works with activating factor VIIa (FVIIa) to form the TF/FVIIa complex (the main promoter of the clotting cascade), and this pathway can be blocked by TFPI, a protease inhibitor (143, 144)