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Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomised clinical trial

Senescent cells are damaged cells that no longer divide but contribute to aging and chronic inflammation

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The vitamin may, however, be offered orally

The mechanism involves capsaicin acting on endothelial TRPV1, causing Ca 2+ influx, which subsequently promotes eNOS phosphorylation and increases NO, BH, and cyclic guanosine monophosphate (cGMP) levels, enhancing vasodilation