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This loss primarily occurs due to co-deletion of the Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A) genewhich encodes the p16 tumor suppressor proteinor through promoter methylation of the MTAP gene (5)

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PMID: 98 LuTYeePPChihSYTangMChenHAregawiDGet al

It should be noted that the accumulation of GSSG affects the glutathionylation of mitochondrial proteins, thus changing their functioning

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