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10.1177/1759720X211015829 Ther Adv Musculoskelet Dis

Common Reconstitution Mistakes Using regular sterile water instead of the correct diluent, causing pH mismatch and poor solubility Injecting diluent directly onto the lyophilized cake rather than down the vial wall Shaking or vortexing the vial, which denatures sensitive compounds Skipping the label, creating traceability gaps that violate standard laboratory procedures Extending storage beyond 7 days for acetic acid water reconstituted solutions Frequently Asked Questions How do I know which diluent to use for my compound

Be patient because it takes time to replenish tissue stores of B12

Inspect the solution: if it is discolored or contains particulate matter that does not dissolve, do not use it

The distinction between PCAC recommendation and actual rulemaking is one that will get lost on a lot of operators who aren't paying close attention