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Mechanistically, NETderived histones bind to endothelial cell TLR2/TLR4 and trigger NFB and MAPKmediated upregulation of adhesion molecules (ICAM1, VCAM1, Eselectin), thereby promoting neutrophil and platelet tethering [81]

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mexicana infection has not only been observed in mice (Grimaldi et al, 1984

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