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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

SCI leads to ROS accumulation in skeletal muscle [40], resulting in oxidative injury, a key contributing factor to skeletal muscle atrophy [41]

In addition, the production of cytokines is elevated in patients that are in a critical state due to their decrease in plasma zinc concentration (137)