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Through experiments in a PCOS mouse model and a KGN GC model, PLB significantly improved ovarian function, regulated hormone levels, enhanced antioxidant capacity, and promoted cell survival by inhibiting the ferroptosis pathway

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It regulates various mediators and pathways, playing a crucial role in the development and progression of PCOS

It binds to HGF with high affinity (Kd = 65 pM) and markedly augments the capacity of HGF to activate c-Met phosphorylation, even at subthreshold concentrations of the growth factor

Given the existence of the specific OCTN1 transporter and the selective accumulation in neural and metabolically active tissues, this raises the question of whether the Western decline in mushroom consumption compared to traditional cultures in Asia, where mushrooms have been a staple food for thousands of years may contribute to a chronic undersupply that could correlate with the rise of neurodegenerative disease

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