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Recently, Kim et al confirmed the effect of insulin on GSH levels and GCLC expression in rat hepatocytes and found that of the signaling pathways activated by insulin, PI3K/Akt/p70S6K are involved in mediating the effect while ERK, JNK and p38 MAPK are not (Kim et al., 2004)

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SIRT1 activity may be required for limiting the toxicity of oxidative stress and preserving memory (262), fostering A degradation (586), increase lifespan in higher level organisms (587), and protecting neuronal and vascular cells against oxidative stress (98, 134, 232, 240, 438, 502, 510, 550, 551, 554, 555, 588)