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To evaluate the effect of Epitalon on different stages of carcinogenesis, different treatment regimens were used: during the tumor initiation stage, during the tumor-promotion stage, or during the entire process of tumor development

Samples were collected at predetermined time points and analyzed to determine cumulative drug permeation [47, 48]

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Mol Cell Biol (2004) 24(21):9630

Male Swiss mice were exposed to aspartame at a dose of 80 mg/kg bw (2.5 mL/kg, prepared in 0.9% saline solution) by gavage for 12 weeks