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During auto-oxidation, excess glucose binds (protein glycation) [37] to lysine and valine residues in tissue and plasma proteins

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The initiating factor of ALS is hypothesized to be a combination of multigenic and environmental factors [7] acting as multiple hits toward a threshold at which genetic and epigenetic changes converge into a pathologic cycle of degeneration

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[DOI] [PubMed] Buie T, Campbell DB, Fuchs GJ, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H

Leukemia 30:399408 de Weers M, Tai YT, van der Veer MS, Bakker JM, Vink T, Jacobs DC et al (2011) Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors