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G-protein-independent signaling [edit] Although they are classically thought of working only together, GPCRs may signal through G-protein-independent mechanisms, and heterotrimeric G-proteins may play functional roles independent of GPCRs

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Some of the primary genes impacted are COL1A1 (matrix), VEGFA (angiogenesis), IL6 (inflammation), and SOD2 (oxidative defense)

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