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lucidum have been demonstrated so far, including antioxidant [33], hypoglycemic [34], immunomodulatory [35], antidiabetic [36, 37], and anticancer [38] activity

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JAMA 83(26):20822085 Dietrich KN, Ware JH, Salganik M, Radcliffe J, Rogan WJ, Rhoads GG, Fay ME, Davoli CT, Denckla MB, Bornschein RL, Schwarz D, Dockery DW, Adubato S, Jones RL (2004) Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry

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Oxidative stress-induced mitochondrial fission has been implicated in RGC degeneration, with the loss of proteins such as AKAP1 leading to Drp1-mediated mitochondrial fission, increased ROS production, and diminished ATP synthesis, further contributing to RGC death (127, 128)