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Various studies suggest that GHS-R1a specifically forms dimers with the following hormone and neurotransmitter receptors: somatostatin receptor 5, [6] dopamine receptor type 2 (DRD2), [11] melanocortin-3 receptor (MC3R), and serotonin receptor type 2C (5-HT 2c receptor)

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Ipamorelin is a selective growth hormone secretagogue (GHS) that mimics ghrelin to stimulate the release of growth hormone (GH) from the pituitary gland

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The conjugate, which is a Michael adduct (because the reaction is a Michael addition), can rearrange to form a cyclic hemiacetal (Fig