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After choosing the best model, we proceeded with stepwise variable deletion to minimize the AIC

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Journal of Neurology, Neurosurgery & Psychiatry, 69(2), 228-232

Edema (limited use due to weak diuretic effect) Side Effects: - Metabolic acidosis (due to bicarbonate loss) - Hypokalemia - Paresthesia (tingling) - Renal stones (alkaline urine increases stone risk) - Drowsiness, confusion - Sulfa allergy reactions (as CAIs are sulfonamide derivatives) Contraindications: - Severe hepatic or renal dysfunction - Addisons disease - Pre-existing electrolyte imbalance - Sulfonamide hypersensitivity Precautions: - Monitor serum electrolytes and acid-base balance - Use with caution in patients with pulmonary obstruction (CO retention risk) Pregnancy Category: Use with caution topical forms (e.g., dorzolamide) may be safer than systemic forms

doi:10.3390/nu9101085

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