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10.1016/j.cell.2019.09.001 63 MaF.WuT.ZhaoJ.JiL.SongA.ZhangM.et al

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Beyond their well-known role as miRNA sponges, studies have revealed that circRNAs can also interact with RNA-binding proteins (162), regulate RNA splicing and transcription (163,164), and undergo translation into functional peptides or proteins (165,166)

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Following the treatment course, the MASI score of the included patients was increased from 41.7% to 85%, however, the melasma severity scale (MSS) was decreased from moderate (score 2) to mild (score 1) during the treatment course (Kusumawardani et al., 2019)

Where: Vc = Volume of paw edema in CTRL rats