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First, pro-inflammatory cytokines can activate NOX and iNOS, leading to the production of ROS by IECs, neutrophils, and macrophages

Declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of Zhengzhou University Peoples Hospital

Dobrinas et al., 2011

Barlina et al

High sensitive C reactive protein (hsCRP) assessment: Briefly, serum samples were diluted with a ratio of 1/101 with the diluent solution

Wrinkle reduction Yes Regeneration and healing Yes Antioxidant effects Yes Improved skin elasticity Yes Safety of use Yes Scientific data and sources Research summary Level of evidence Preliminary Number of included studies: 20 8 studies 5 studies 4 studies 1 study 1 study 1 study Final comment: Although systematic literature analyses and results from in vitro and animal model studies indicate the effectiveness of GHK-Cu in skin regeneration and wrinkle reduction, there are no direct randomized controlled trials in humans