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introduced Zr into a manganese porphyrin-based MOF (Mn-MOF) to construct a biocompatible nanosensitizer along with the capacity of GSH exhaustion-enhanced ferroptosis (Figure 5F) (Xu et al., 2021)

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Studies have shown that the main factor contributing to the elevation of hypothalamic-pituitary activity is the increased production of corticotropin-releasing hormone (CRH)

It was originally assumed that Schwann cells invaded the CNS following a breach of the glia limitans, but another mode of Schwann cell contribution to CNS remyelination is now recognized (Blakemore, 2010)

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Thus, finding efficient inhibitors that can outcompete the substrate could be potentially difficult