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Yuh B, Tate J, Butt AA, Crothers K, Freiberg M, Leaf D, et al

GRK4 variants can increase the activity of GRK4 [28, 77,78,79, 93]

This fact is often ignored in the medical field

As previously shown ( CYS4 -overexpression (OE) in yeast favors cysteine and glutathione synthesis at the expense of methionine and homocysteine (Figure 1A), leading to a decreased ability of yeast cells to grow without external supply of methionine (Figure 1B)