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Of the 8 patients who received combination therapy with a PD-1 inhibitor and a CTLA-4 inhibitor, 2 (25%) had an immune-related adverse event, with 1 of these patients having 3 immune-related adverse events

FIN56 promotes GPX4 degradation while depleting coenzyme Q10, creating a dual node pressure on the lipid antioxidant network that can overcome single target resistance and broaden ferroptosis induction across resistant states (87, 88)