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Semin Oncol 26 : 6367 Valik D, Radina M, Sterba J, Vojtesek B (2004) Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy

Researchers started describing it as a genome reset, because the pattern in aged cells shifted back toward what youd expect from younger tissue (PMID: 25815981)