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Following a comprehensive cellular and cytokine profiling by flow cytometry across distinct immunological niches, we identified CD4 + T cells residing in the dural meninges as a source of disease-associated IL-17A in 5xFAD mice, which was downregulated by targeting CD38, with no effect on IFN-- or IL-4-producing T cells (Fig

Cel 81 (2), 398407

NIH grants 5P01CA120964-05 and DanaFarber/Harvard Cancer Center Support Grant 5P30CA006516-46 (J.M.A.)

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The experimental outcomes were evaluated using xCELLigence, flow cytometry, immunofluorescence, western blotting, and metabolomics