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In the Phase 2 Lancet trial, orforglipron 45 mg reduced HbA1c by up to 2.1 percentage points at 26 weeks, exceeding the reduction achieved by dulaglutide 1.5 mg (the active comparator)

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This may be repeated daily or weekly as needed

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Previous studies have reported inconsistent results when comparing oral, sublingual, and intramuscular administration, often limited by small sample sizes or heterogeneous populations ( The aim of this systematic review and meta-analysis was to critically assess and compare the effectiveness of different vitamin B12 administration routes in correcting deficiency

A: Up to 28 days for multi-dose use