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Increased ATP/ADP ratio induces the closure of ATP-sensitive potassium (K ATP ) channels, leading to membrane depolarization followed by activation of voltage-gated Ca 2+ channels (VGCC) and Ca 2+ influx

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This pronounced increase in Ssu72 expression was also observed in eWAT from HFD-fed male mice compared with normal chow diet (NCD)-fed male mice (Fig

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