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In both HCC models, mice from control and Leu+ groups had to be euthanized during the treatment course, whereas mice from Leu- group survived longer (Fig

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10.1186/s41936-024-00371-z 28 ChaneyS

They also increase mitochondrial glutathione levels by activating the Nrf2 signaling pathway, which plays a pivotal role in triggering inflammation.[xxvii] The ketogenic diet also stimulates autophagy in the brain, helping to clear away cellular damage to neurons.[xxviii] Finally, the ketogenic diet effectively reduces neuroinflammation by inhibiting the NF-kB inflammasome and producing the pro-inflammatory cytokines TNF-alpha and COX-2.[xxix] Patients with concussions and post-concussive syndrome can be challenging to treat

Lee SK, Kim SH, Cho GY, Baik I, Lim HE, Park CG, Lee JB, Kim YH, Lim SY, Kim H, Shin C

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