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Begin within days of surgery continuing through rehabilitation phase (3-6 months typically)

10.1523/JNEUROSCI.2855-11.2011 199 MelkeJ.Goubran BotrosH.ChasteP.BetancurC.NygrenG.AnckarsterH.et al

Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium

Potential interactions with drugs metabolized by methyltransferases should be considered

It binds to skeletal muscle cells and activates AMPK, the enzyme responsible for switching cellular metabolism from anabolic (storage) to catabolic (burning) states

Ishibashi K, Ishii K, Sugiyama G, Sumida T, Sugiura T, Kamata Y, Seki K, Fujinaga T, Kumamaru W, Kobayashi Y (2018) Deregulation of nicotinamide N-methyltransferase and gap junction protein alpha-1 causes metastasis in adenoid cystic carcinoma