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In March 2026, Roche reported that the Phase 2 ZUPREME-1 trial produced mean body-weight reductions of up to 10.7% at week 42 versus 1.7% with placebo under the reported analysis

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Specifically, the NO-specific effects of NO-agents i.e

Its still unclear which specific components of the NF-B signaling pathway are critical and how they might function during the differentiation of exhausted T cells