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Human macrophage polarization in vitro: maturation and activation methods compared

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Among the 122 proteins downregulated in PQS-treated shCNMT RAW264.7 macrophages, the iron uptakeassociated single-pass membrane receptor TFR1 was directly related to ferroptosis as the critical downstream effector of CNMT 15

Overall, whilst there were some differences in the phenotype observed in different cell models, as you may expect due to differences in the expression of APP and its secretases, RABGAP1 KD/KO and overexpression consistently resulted in aberrant APP processing

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