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Recent studies have demonstrated that targeting deubiquitinases can effectively reduce the post-translational levels of NRF2 and YAP proteins, thereby decreasing the growth and chemoresistance of pancreatic cancer cells [124]

CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1alpha-mediated glycometabolism alteration

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These results indicate that long-term kefir intake mitigates stress-induced behavioral and physiological alterations, likely through modulation of immune and oxidative stress pathways