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By mimicking the GLP-1 hormone, it stimulates insulin secretion

Quality determines outcomes more than any other factor

Individual results vary.

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The technique is contraindicated in pregnancy and breastfeeding, in active acne or skin infection, within 6 months of oral isotretinoin, in patients with keloid scarring history, and on anticoagulant therapy without physician clearance

A 2022 study in Diabetes, Obesity and Metabolism showed that NNMTi treatment combined with reduced-calorie diet "promoted dramatic whole-body adiposity and weight loss in diet-induced obese mice, rapidly normalizing" weight parameters