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PSSG formation from condensation of protein sulfenic acid and GSH disulfide S-oxide (GS(O)SG), a dimer of GS(OH) the formation of which is catalyzed by metals [63, 64]

406 It was also proved that downregulation of Mfn2 occurs in conditions such as liver cancer, non-alcoholic steatohepatitis, and liver fibrosis

Plasma membrane GSH efflux pumps

On a cellular level, O 2 is integral to the process of energy generation during aerobic respiration

Monteiro HP, Winterbourn CC (1989) 6-Hydroxydopamine releases iron from ferritin and promotes ferritin-dependent lipid peroxidation

Together, these findings suggest that peripheral biomarkers have the potential to become a valuable diagnostic aid across multiple forms of dementia, offering a rare blend of accessibility, biomarker specificity, and emerging commercial viability