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The nuclei and slides were stained and mounted by prolong gold antifade reagent with DAPI (Cayman Chemical 14285) followed by imaging using the Zeiss LSM880 with Airyscan (RRID:SCR_020925) Confocal Scanning Microscope in the Quantitative Light Microscopy Core (QLMC) at the UTSW or Zeiss Axioscan 7 Digital Slide Scanner (RRID:SCR_027284) at the Whole Brain Microscopy Facility at the UTSW

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7), we emphasize that the ICV component served primarily as a preclinical proof-of-concept to validate direct CNS engagement for neural repair