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The kinetic data demonstrated that JMF4073 inhibits TMPK and CMPK in a mixed inhibitory mode as indicated by the increased Km for the substrates with decreased Vmax

Scientific Communications: SVD and cogniton 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.01 - PREVENTION O - ESOC25-2242 INVESTIGATING THE ASSOCIATION OF A BRAIN CARE SCORE WITH STRUCTURAL BRAIN CHANGES AND COGNITIVE IMPAIRMENT Jenna Schellin 1 , Susanne Sehner 1 , Marie Neumann 1 , Marvin Petersen 1 , Felix Ngele 1 , Sanjula Singh 2,3,4,5 , Jonathan Rosand 2,3,4,5 , Nils Schumacher 6 , Birgit-Christiane Zyriax 1 , Raphael Twerenbold 1 , Bastian Cheng 1 , Gtz Thomalla, Mrit Jensen 1 1 University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2 Broad Institute of MIT and Harvard, Cambridge, MA, United States, Boston, United States, 3 Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, United States, 4 Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States, 5 Department of Neurology, Massachusetts General Hospital, Boston, United States, 6 Faculty of Psychology and Human Movement, Institute of Human Movement Science, University of Hamburg, Hamburg, Germany Background and Aims: The Brain Care Score (BCS) aims to encourage patients to change their behavior in order to modify risk factors and prevent dementia

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doi: 10.1016/j.pneurobio.2015.12.008 51 FanZ.WirthA