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To understand why senescent cells are more prone than normal counterparts to undergo ferroptosis on GPX4 inhibition, we used fluorescence probes to analyse ROS, levels of Fe 2+ and lipid oxidation in senescent cells

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One directly affects the somatotropic cells of the anterior pituitary, itself inhibiting further release of GH, whilst the other affects GH releasing hormone and somatostatin release from the hypothalamus to reduce the secretion of GH

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10.1177/1179546817694558 [DOI] [PMC free article] [PubMed] [Google Scholar] Berlanga-Acosta J., Guillen-Nieto G., Lopez-Mola E., Herrera-Martinez L