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Description

Puche JE, Muoz , Garca-Magario M et al (2015) Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy

Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment

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doi: 10.1111/j.1468-1293.2010.00906.x

However, murine studies showed no acute toxicity at doses up to 100 mg/kg over 11 weeks, and limited human pilot data through 2026 reported no serious adverse events