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TLYYH intervention significantly reversed these changes, increasing the relative abundances of Lactobacillus , Akkermansia , and Odoribacter , while significantly reducing the abundances of Helicobacter and Desulfovibrio

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In its role in remethylating homocysteine, betaine generates methionine, which upon enzymatic conversion to a key methyl donor, S -adenosylmethionine (SAM) is utilized in a variety of essential transmethylation reactions (22)