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Though the pathogenesis of hypothyroid myopathy is not entirely known, proposed mechanisms include altered glycogenolytic and oxidative metabolism, altered expression of contractile proteins, and neuro-mediated damage

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RETURN TO TOP Progression & Prognosis Left atrial enlargement Left ventricle enlargement Increased mitral regurgitation Congestive heart failure Atrial fibrillation (AF) Chordae tendineae rupture Left atrial tear Atrial septal defects and aneurysms Pulmonary hypertension (PH) Mitral regurgitation severity index (MRSI) Sudden death The progression of mitral valve disease can be rapid or slow

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