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(C: control, S: A

Severe or prolonged B12 deficiency can lead to a range of neurological manifestations, including peripheral neuropathy, which may present as pain, paraesthesia (pins and needles), or altered sensation in the extremities

Their further synthesis is disrupted and cannot occur regularly, resulting in symptoms such as frequent breakdowns, spontaneous bruising, weakness, and nighttime fever

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Effective vitamin B12 replacement should correct a macrocytic anaemia within 2 months and improve or correct neurological signs and symptoms within 6 months

(Note: While categorized under research compounds, 5-Amino-1MQ is a synthetic small-molecule organic compound rather than a structured amino acid peptide sequence.)