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10.1016/j.yfrne.2013.08.001 83 RizzutoR.De StefaniD.RaffaelloA.MammucariC

These modifications not only hinder their microcirculatory movement but also function as molecular signals that facilitate their identification and removal by the reticuloendothelial system

A provider diagnoses PCOS when a woman meets two of the three Rotterdam criteria: Hyperandrogenism (high androgens based on lab tests or symptoms) Irregular or anovulatory menstrual cycles Signs of polycystic ovaries on ultrasound Elevated androgens (like DHEA and testosterone) are part of the diagnostic criteria, affecting 60 to 80% of women with PCOS