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This process promotes the transdermal delivery of both hydrophobic and hydrophilic metabolites, enhances the deep penetration of active metabolites, and improves the anti-aging and whitening properties of products (McMullen and DellAcqua, 2023

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Note any treatment given and any relevant blood tests

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Thus, FcR function seems to have a crucial role in protection mediated by the polyclonal antibodies provided by passive or active immunization, although as noted above, individual mAbs may not require FcR function for protection