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76 Class C GPCRs, the glutamate receptors, are unique in their large ECDs, conserved venus fly traps (VFTs), cysteine-rich domains (CRDs) on the ligand binding sites, and constitutive dimers for receptor activation

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doi: 10.1046/j.1365-2362.2000.00736.x 153 RoedererMElaSWStaalFJHerzenbergLAHerzenbergLA

Withhold pemetrexed in patients with a creatinine clearance of less than 45 mL/minute [see Dosage and Administration (2.3)]

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