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Brenner H, Roder V, Hodel B, et al

Anatomically and functionally distinct lung mesenchymal populations marked by Lgr5 and Lgr6

This is why it is often referred to as a mushroom, although it is not a fungus

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Recently, a growing body of evidence suggests that aberrant activation of HGF/c-Met signaling is associated with resistance of target therapies (Corso and Giordano, 2013), including sorafenib