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Biochemistry 39:1539915409

doi: 10.1002/adfm.201402618

Under these oxidizing conditions, S-glutathionylation may serve as a reservoir for GSH inside the cell and may also protect from irreversible oxidation to sulfinic and sulfonic acid, which leads to proteasomal degradation of the protein (209)

Denoyer, D

Abnormal Tumor Vasculature Tumor vessels are often irregular and tortuous, resulting in unstable blood flow and poor perfusion, effectively limiting immune cell infiltration [181]

We might therefore predict that other metabolites would also exhibit reductions correlated with reductions in glutathione and glutamate