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Imagine you found a lamp on the beach, and a genie came out and granted you a wish, Maris said

10.3390/ijms22095010 4 AquilanoK.BaldelliS.CirioloM

HNF1 drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)

For example, patients with lupus often have glutathione deficiency, and studies have shown that replenishing it significantly reduces their symptoms

The study also found reductions in liver fat as measured by controlled attenuation parameter (CAP scores), plus improvements in triglycerides and other metabolic markers

These NADPH-generating reactions are catalyzed by MTHFD1 in the cytosol and MTHFD1L, MTHFD2L, and ALDH1L2 in the mitochondrial matrix compartment (Fig