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By analyzing alterations in various humoral metabolites secreted in response to external interventions, metabolomics provides a holistic, dynamic, integrated, and analytical perspective

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For instance, Whitehouse et al

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When extracellular Cu 2+ enters the mitochondrial compartment of cells, FDX1 reduces Cu 2+ to Cu + , resulting in the oligomerization of DLAT protein and the downregulation of Fe-S cluster protein expression