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Molecular basis for hormone recognition and activation of corticotropin-releasing factor receptors

Similar to other neurotrophins, BDNF is first synthesized as a precursor protein, named pro-BDNF of 32 KDa, which is cleaved by different proteases to produce either the mature form of 14 KDa, or the truncated form of 28 KDa

Rausch, C., Hoof, I., Weber, T., Wohlleben, W., Huson, D

Nature 521, 173179

To help understand the underlying rewiring of iPSCs during differentiation to HLCs, we utilize proteomic analysis to help identify the key factors involved in iPSC response to stimuli